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KMID : 0043320120350040633
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Archives of Pharmacal Research
2012 Volume.35 No. 4 p.633 ~ p.638
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Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors
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Kinger Mayank
Park Yong-Dae
Park Jeong-Hoon
Hur Min-Goo
Jeong Hyung-Jae
Park Su-Jin
Lee Woo-Song
Kim Sang-Wook
Yang Seung-Dae
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Abstract
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A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 ∝M.
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KEYWORD
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Anti-influenza activity, Synthesis, Neuraminidase, 1, 3-Diarylprop-2-en-1-ones
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